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Ranked 14th among 30 Folic Acid products.
Ranked 9th among 12 Vitamin B9/Folate products.
Available here from $ 13.5

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Overview

Life Extension High Potency Optimized Folate is a dietary supplement centered on L-methylfolate, the metabolically active form of folate. It provides 5-MTHF, which is the biologically available form of folate that the body can use without needing to convert it first. The formula is presented as a high potency tablet and is designed to support healthy homocysteine metabolism within the normal range.

This product is also positioned to support both cardiovascular and cognitive health. Because not everyone efficiently converts folate into its active form, the supplement is formulated to supply 5-MTHF directly rather than relying on a conversion step. The label also identifies the product as gluten free and Non GMO LE Certified.

Key Features & Benefits

  • Provides L-methylfolate, the active form of folate.
  • Supplies 5-MTHF, an ultra-bioavailable folate form.
  • Formulated as a high potency folate supplement.
  • Designed to help maintain homocysteine levels already within the normal range.
  • Supports cardiovascular health.
  • Supports cognitive health.
  • Tablet form for daily use.
  • Gluten free.
  • Non GMO LE Certified.

Specifications

  • Brand: Life Extension
  • Product name: High Potency Optimized Folate
  • Supplement type: Dietary supplement
  • Active ingredient: L-methylfolate (5-MTHF)
  • Dosage form: Tablet
  • Intended use: Supports cardiovascular and cognitive health; helps maintain healthy homocysteine levels
  • Dietary claims: Gluten free; Non GMO LE Certified

Suggested Use

Take one tablet daily with food, or use as directed by a healthcare practitioner. The label advises reading the full label carefully before use.

Other Ingredients

Microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, and vegetable stearate.

Allergen & Dietary Information

This formula is listed as gluten free and Non GMO LE Certified.

Warnings

  • Do not exceed the recommended dose.
  • Keep out of reach of children.
  • Do not buy the product if the outer seal is broken or missing.
  • Consult a healthcare provider if you are at risk of vitamin B12 deficiency, since high dose folate may conceal signs of that deficiency.
  • Speak with a physician before use if you are being treated for a medical condition or if you are pregnant or lactating.

Storage

Store the bottle tightly closed in a cool, dry place.

This folate supplement delivers 5-MTHF in a bioavailable form to support healthy homocysteine balance, with a formula designed to provide active folate directly rather than relying on conversion by the body.

Disclaimer

The information provided on this page is intended for general informational purposes only and should not be considered medical advice. Product formulations, ingredients, packaging, and labeling may change over time. Always read the label, warnings, and directions provided with the product before use. If you are pregnant, nursing, taking medication, or have a medical condition, consult a qualified healthcare professional before using any dietary supplement.

Life Extension High Potency Optimized Folate FACTS AND ALTERNATIVES COMPARISON

  9
Life Extension High Potency Optimized Folate Life Extension
Supplement Rating
Life Extension High Potency Optimized Folate
1
Life Extension Optimized Folate Life Extension
Supplement Rating
Life Extension Optimized Folate
17
Jarrow Formulas Folic Acid Jarrow Formulas
Supplement Rating
Jarrow Formulas Folic Acid
2
Thorne Research 5-MTHF Thorne Research
Supplement Rating
Thorne Research 5-MTHF
Serving Size 1 Vegetarian Tablet 1 Vegetarian Tablet 1 Capsule  One Capsule
Price/Serving $0.46 $0.11 76% $0.13 72% $20.23 4298%
Servings Per Container 30 100 233% 100 233% missing substance or information*
Vitamin B9 5000 mcg (6S)-5-Methyltetrahydrofolic acid, glucosamine salt] 1000 mcg [as (6S)-5-Methyltetrahydrofolate Calcium salt] 800 mcg 1.7 mg DFE (1 mg as 5-Methyl-tetrahydrofolate†)

*Some information on the Life Extension High Potency Optimized Folatelabel may be missing, or it may have been written incorrectly. We work hard to keep the information accurate & up to date. Please let us know if you discover any errors.

AI consultant

This content is for informational purposes only and is not a substitute for professional medical advice. Consult a qualified healthcare provider before taking any supplement.