Understanding Coffee: A Deeper Dive

Understanding Coffee: A Deeper Dive

Coffee – you know it, you’ve tried it and if you’re an American, chances are you’re in love with it. It’s everywhere and there are too many different blends to count. There’s also a lot of chemistry under the hood, driving the many positive and negative effects you might already know about.

What We Mean By "Coffee"

At its most basic, coffee refers to the brewed drink prepared from roasted coffee beans, the seeds of berries from the Coffea plant. Originating in tropical regions of Africa, these beans have traversed continents and centuries to become one of the world's most beloved beverages.

Common Misconceptions

Many believe that the term "coffee" refers solely to the caffeinated drink that keeps us awake. However, coffee is a complex concoction of over 1,000 compounds, each contributing to its unique aroma, flavor, and health effects. That’s right! It’s a mixed recipe! It's more than just caffeine. Also, not all coffee is created equal. Differences in bean variety, growing conditions, and processing methods can result in a wide spectrum of flavors and potencies.

Coffee and Mortality: A Historical Perspective

Coffee’s impact on health has been a topic of debate for centuries. The direct effects are clear. It helps you stay awake sometimes. But it took a lot of research to understand the actual chemistry of how coffee interacts with your body.

The Initial Beliefs About Coffee Consumption and Risks

When coffee first made its appearance in Europe in the 17th century, many believed it to be a medicinal tonic. Some saw it as a dangerous and intoxicating substance. In some regions, coffee was even banned, over concerns of "unnatural" heating properties and the fact that coffee seems to make people more sociable.

Some believed it could cure ailments, while others thought it could shorten your lifespan. But as is the case with many newly introduced items, time and research would serve to separate myth from fact.

The Turning Point: The 2018 UK Biobank Study

Fast forward to the modern era, and the debate on coffee's health effects is still ongoing, albeit with more scientific research. For years, studies produced conflicting results.

However, a significant turning point came with the 2018 UK Biobank study. This ambitious project tracked the health and habits of nearly half a million people over a decade. With its vast sample size and meticulous methodology, the study was poised to provide some of the clearest insights into coffee's long-term effects.

Key Findings and Statistics

The results were surprising and informative:

Regular Coffee Drinkers Had Longevity Benefits: Participants who consumed coffee regularly had a slightly lower risk of death over the 10-year period than those who didn't.

Both Caffeinated and Decaffeinated Coffee Showed Benefits: Interestingly, the longevity benefits weren't exclusive to caffeinated coffee. Decaf drinkers also showed similar trends, suggesting that compounds other than caffeine in coffee contribute to its health effects.

No Increased Risk for Cardiovascular Diseases: One of the long-standing concerns with coffee was its impact on heart health. However, the study found no increased risk for cardiovascular diseases among coffee drinkers, even for those consuming up to 7 cups a day.

Potential Protective Effects Against Certain Diseases: Coffee consumption was linked to a lower risk of diseases like liver disease, certain types of cancers, and neurodegenerative conditions.

While the UK Biobank study didn't establish causation, its findings added substantial weight to the idea that coffee, when consumed in moderation, might be more of a friend than a foe to our health.

This shift in understanding marked a new era in our relationship with coffee.

The European Perspective: The EPIC Study

Europe, with its rich coffee culture that varies from the espresso shots of Italy to the café au laits of France, has long been a hub for both coffee consumption and research. As we dive into the European perspective on coffee and health, one study stands out not just for its scale but also for its depth: The European Prospective Investigation into Cancer and Nutrition, commonly known as the EPIC study.

Overview and Methodology

Spanning a decade and encompassing over half a million participants from ten European countries, the EPIC study is one of the most comprehensive investigations into diet, lifestyle, and chronic disease. With its vast sample size and diverse population, the study aimed to account for the variety in dietary habits and health outcomes across different European nations.

Participants underwent detailed dietary assessments, lifestyle questionnaires, and regular health check-ups. Among the myriad of foods and habits analyzed, coffee consumption and its potential link to various health outcomes were of particular interest.

Outcomes Compared to the UK Biobank Findings

While the EPIC study explored a wide array of dietary factors, its findings on coffee mirrored and, in some areas, expanded upon those of the UK Biobank:

Overall Mortality: Just like the UK Biobank, the EPIC study found that regular coffee drinkers, whether they consumed decaf or regular, had a slightly lower risk of all-cause mortality compared to non-drinkers.

Digestive Diseases: Coffee consumption was inversely associated with mortality from digestive diseases. This was particularly evident for liver conditions, reaffirming the protective effects of coffee on liver health.

Circulatory Diseases: Unlike the neutral findings of the UK Biobank regarding cardiovascular health, the EPIC study suggested a more nuanced relationship. Moderate coffee consumption seemed protective against cerebrovascular diseases, but excessive consumption (beyond certain thresholds) might increase the risk for certain cardiovascular outcomes.

Cancer Mortality: The EPIC study provided further insights into coffee's relationship with cancer. While the overall cancer mortality wasn't significantly affected by coffee intake, there were protective effects observed against certain specific types of cancers, complementing the findings of other studies we'll explore later.

The EPIC study, with its pan-European perspective, not only reinforced many of the UK Biobank's findings but also offered nuanced insights into how coffee might interact with various health outcomes. These large-scale studies serve as a testament to the evolving understanding of coffee in health research, moving from apprehension and doubt to a more informed and balanced perspective.

Coffee's Protective Role against Cancer

Coffee, once branded as a potential carcinogen, has in recent decades undergone a transformation in the eyes of the scientific community. An array of studies has emerged, highlighting not just coffee's neutral stance on cancer but also its potential protective effects against certain types of the disease.

Preliminary Studies and Findings

Historically, coffee was viewed with suspicion due to its association with certain lifestyle factors such as smoking and alcohol consumption. It’s a common trope – morning coffee with a cigarette. However, science has found no account connection between the two. One does not lead to the other in any way.

Antioxidants in Coffee: One of the hallmarks of cancer is oxidative damage. Coffee, being rich in antioxidants, helps combat this damage. These bioactive compounds neutralize free radicals in your body, reducing oxidative stress, which can initiate carcinogenesis.

DNA Repair: Some compounds in coffee have been found to enhance the self-repair mechanism of DNA, a crucial process given that DNA damage can lead to mutations and, subsequently, cancer.

Anti-inflammatory Properties: Chronic inflammation is a known driver of many cancers. Coffee exhibits anti-inflammatory properties that could potentially stave off such diseases.

Breast cancer, one of the most researched types in relation to coffee consumption, has yielded some promising findings. Among postmenopausal women, regular coffee consumption has been associated with a reduced risk of developing breast cancer.

Hormone Regulation: Coffee, particularly its compounds like lignans and isoflavones, might influence estrogen metabolism, leading to a more favorable hormonal environment that reduces the risk of hormone-sensitive breast cancers.

Cell Cycle Regulation: Some studies suggest that coffee compounds can inhibit the growth and proliferation of breast cancer cells, leading to slowed tumor progression.

The Journal of Oncology Bulletin on Recurrence Prevention

An exciting turn in coffee research came with a bulletin from the Journal of Oncology. Their analysis highlighted:

Reduced Recurrence: Among certain cancer survivors, regular coffee consumption appeared to reduce the risk of cancer recurrence and improve survival rates.

Improved Treatment Outcomes: Some findings suggest that coffee, when consumed alongside certain cancer treatments, might enhance their efficacy. However, these findings are preliminary and need further validation.

The protective role of coffee against cancer is promising, but it’s not a cure or a guaranteed prevention method. Still, it’s a welcome addition to your diet and it could improve your overall health and wellbeing in various ways.

Coffee and Brain Health

Coffee supplement for brain health, promoting cognitive function and mental alertness.

Memory Enhancement and Risk Reduction for Neurodegenerative Diseases

Coffee's key ingredient, caffeine, is a central nervous system stimulant known for its short-term brain-boosting effects. But the story doesn't end with just staying alert. Here's a deeper look:

Enhanced Short-term Memory: Regular moderate coffee consumption has been shown to boost episodic memory, attention, and mood. The stimulant properties of caffeine can lead to heightened alertness, making it easier to retain and process information.

Protection Against Alzheimer's and Parkinson's: Several studies indicate that habitual coffee drinkers have a lower risk of developing Alzheimer's and Parkinson's disease. While the mechanisms are not entirely clear, it is believed that coffee's anti-inflammatory and antioxidant properties play a vital role.

Brain Plasticity: Some evidence suggests that compounds in coffee can promote the growth and maintenance of neurons, a process vital for learning and memory.

Mood Elevation and Cognitive Function Improvement

Coffee isn't just about keeping you awake—it may also play a role in your mood and overall mental wellbeing:

Antidepressant Effects: Regular coffee consumption has been linked to a lower risk of depression. The combination of neurotransmitter modulation by caffeine and the antioxidants in coffee might have a mood-elevating effect.

Reduced Risk of Stroke: Some epidemiological studies suggest that moderate coffee consumption is associated with a reduced risk of stroke, which can have profound effects on cognitive function.

Cognitive Reserve: Long-term, regular coffee drinking may increase cognitive reserve, the brain's resilience to pathological damage. This means coffee might help the brain maintain functionality despite potential challenges or damages it may face.

Still, you have to remember that moderation is key. Coffee is a potent drink. It’s not advised that you drink it constantly in hopes of improving your health.

The Chemical Magic: Compounds in Coffee

Coffee compounds with antioxidants, caffeine, and polyphenols for health benefits.

Caffeic Acid and Its Properties

The Basics: Caffeic acid, not to be confused with caffeine, is a type of polyphenol found abundantly in coffee. It’s one of the many compounds that contribute to coffee's antioxidant properties.

Antioxidant Powerhouse: Caffeic acid effectively neutralizes harmful free radicals in the body, which can contribute to chronic diseases and aging.

Anti-inflammatory Benefits: Inflammation plays a role in many chronic diseases. Caffeic acid has shown potential in reducing inflammation, further amplifying coffee’s potential health benefits.

Phenols in Coffee and Their Antioxidant Role

Natural Defenders: Phenolic compounds, a broad group of molecules found in plants, are abundant in coffee. They are recognized for their potent antioxidant activity, which can protect our cells from damage.

Synergistic Effects: The phenols in coffee don't just work independently; they often act synergistically, meaning that their combined antioxidant effect can be greater than the sum of their individual effects.

Caffeic Acid, Chlorogenic Acid, and Ferulic Acid

Chlorogenic Acid: Another dominant antioxidant in coffee, chlorogenic acid, is linked with potential benefits like weight loss, reduced blood pressure, and improved mood.

Ferulic Acid: Though present in smaller amounts compared to the other acids, ferulic acid boosts the antioxidant capabilities of caffeic and chlorogenic acids, showcasing how these compounds can complement each other.

The Multifaceted Benefits of Coffee: From Antitoxic to Cardioprotective

Liver Protector: Coffee, thanks to its combination of compounds, has been associated with a lower risk of liver diseases, including liver cirrhosis and liver cancer.

Heart Health: Moderate coffee consumption may support heart health by improving endothelial function and reducing inflammation.

Antitoxic Effects: Coffee can help stimulate the liver to produce enzymes that aid in detoxifying certain carcinogens, adding another layer to its potential cancer-protective effects.

Interactions and Contraindications

Medication Interactions: Coffee can affect how certain medications work, especially those related to depression, blood pressure, and heart rhythms. Always consult a healthcare professional if you’re on medication and a regular coffee drinker.

Certain Conditions: People with anxiety disorders, certain heart conditions, or those sensitive to caffeine should approach coffee consumption with caution.

Coffee's Role in Diabetes Management

Diabetes, a condition affecting millions worldwide, has been the subject of countless studies and research projects. Interestingly, coffee has emerged as a notable player in the dialogue surrounding diabetes management and risk reduction.

The Dual Nature of Coffee's Impact on Blood Glucose

Short-term Effects: Acutely, caffeine can elevate blood sugar levels. After consuming caffeine, the body might reduce its insulin sensitivity, meaning that for a short period post-consumption, your body may require more insulin to handle sugar effectively. This is why some people experience a temporary rise in blood sugar right after drinking coffee.

Long-term Effects: On the flip side, long-term and regular coffee consumption has been associated with a reduced risk of developing type 2 diabetes. Multiple studies have shown that people who drink more coffee (both caffeinated and decaffeinated) have a lower risk of getting this condition.

The Intricate Process of Glucose and Glycogen Balance

Glycogen Storage: The body stores excess glucose as glycogen in the liver. After intense physical activity or long periods without food, these glycogen reserves are utilized.

Coffee's Influence: Coffee consumption can influence how our body uses glycogen and how it reacts to insulin, the hormone responsible for glucose uptake by cells. This intricate dance between glucose, glycogen, and insulin plays a significant role in managing diabetes and overall metabolic health.

The Role of Caffeine and Methylxanthines in This Balance

Caffeine: As a central nervous system stimulant, caffeine can increase adrenaline levels in the blood, which in turn raises blood sugar levels. However, the relationship between caffeine and insulin sensitivity is complex and may vary between individuals.

Methylxanthines: These are a group of compounds found in coffee, with caffeine being the most prominent. They can influence various physiological processes, including those related to glucose metabolism. The precise mechanisms are still under research, but they may contribute to coffee's long-term protective effect against type 2 diabetes.

Coffee's immediate impact might momentarily affect blood sugar levels, and its long-term consumption has potential protective effects against diabetes. As always, individual responses can vary, so if you are at risk of diabetes, you should monitor your reactions to coffee and consult with healthcare professionals.

Coffee as a Supplement: Dosages and Considerations

Best coffee supplement jar with potent natural ingredients for optimal health benefits.

Benefits and Risks of Concentrated Forms

Standardized Extracts: One of the most significant advantages of using coffee as a supplement is the ability to have standardized doses. Unlike a cup of joe, whose caffeine content can vary based on the type, roast, and brewing method, supplements offer a consistent dosage, ensuring you get the desired amount of active compounds.

Concentration of Beneficial Compounds: Coffee supplements often focus on specific compounds, like chlorogenic acid, which has been linked to several health benefits. These concentrated forms allow users to reap benefits without consuming multiple cups of coffee.

Risk of Overconsumption: The flip side of concentrated supplements is the potential for overconsumption. Because these capsules can contain as much caffeine as several cups of coffee, there's a risk of taking too much, leading to side effects like jitteriness, insomnia, or even more severe complications in sensitive individuals.

Coffee Extracts and Their Potency

Green Coffee Bean Extract: This popular supplement is made from unroasted coffee beans and is rich in chlorogenic acid. It's believed to help with weight loss and regulate blood sugar, though more research is needed to confirm its long-term safety and effectiveness.

Caffeine Pills: Essentially a pure dose of the stimulant found in coffee, these pills can enhance alertness and concentration. However, they lack other beneficial compounds found in coffee.

General Guidelines: For most individuals, a moderate coffee intake, which translates to 3-4 cups a day, is considered safe and might even be beneficial. For supplements, it's crucial to follow the manufacturer's recommendations and consult with a healthcare provider.

Timing Matters: Since caffeine can interfere with sleep, it's best to consume coffee or its supplements several hours before bedtime. This allows the body sufficient time to metabolize the caffeine.

How to Balance Coffee Consumption with Other Stimulants

Synergistic Effects: Caffeine can amplify the effects of other stimulants, like those found in certain medications or even in beverages like tea or energy drinks. It's essential to be aware of total daily stimulant intake to avoid potential overstimulation.

Interactions with Medications: Certain medications can interact with caffeine. For example, theophylline, a drug used to treat asthma, can enhance caffeine's side effects. Always consult with a healthcare provider before combining coffee or caffeine supplements with other medications.

Not All Coffees Are Created Equal

The mosaic of aromas, flavors, and effects that coffee offers is not just a testament to its rich history and global appeal, but also a reflection of the myriad of factors that shape each cup. From the type of coffee bean to the way it's processed and brewed, every choice matters. And when it comes to health benefits or potential risks, it's important to note that not all coffees – or caffeine products – stand on equal ground.

The Lesser Effects of Decaffeinated Coffee

Decaffeinated Coffee: Decaf offers a flavor experience somewhat akin to regular coffee but with the majority of its caffeine content removed. While it retains some of coffee's beneficial compounds, the decaffeination process can reduce the concentration of certain antioxidants. It's a good choice for those who are sensitive to caffeine or want to enjoy a cup in the evening without disturbing their sleep.

The Dangers of Instant Coffee

Compromise on Health Benefits: Instant coffee, while convenient, often undergoes processes that might diminish its content of beneficial compounds. Certain instant coffees might contain additives or preservatives that aren't present in freshly brewed coffee.

Flavor and Aroma: The rapid production and drying processes for instant coffee can lead to a worse flavor and aroma. While some high-quality instant coffees have improved in this department, many still lag behind their freshly brewed counterparts.

Choosing the Right Coffee for You

Acidity: Coffees can vary widely in their acidity, which can influence both flavor and how the coffee affects your stomach. Those with sensitive stomachs might opt for low-acidity coffees.

Roast Level: Light, medium, and dark roasts offer different flavor profiles and caffeine contents. Light roasts, for instance, tend to retain more antioxidants and caffeine, while dark roasts offer a bolder, more robust flavor.

Origin: The terroir, or the environment in which coffee is grown, can have a significant impact on flavor. Single-origin coffees allow drinkers to explore unique flavors from specific regions or even specific farms.


In navigating the world of coffee, your personal preference plays a crucial role. Still, you need to understand the nuances of different coffee types and products to help you make informed choices, not just for taste but also for health benefits.

Your morning cup of coffee holds power. It’s no surprise that countless cultures consider it a breakfast staple, even though it’s a poor replacement for a proper early day meal.




  1. https://examine.com/research-feed/study/dEP4o9/?requirelogin=1
  2. https://examine.com/research-feed/study/9zjQP9/?requirelogin=1
  3. Said MA, Verweij N, van der Harst P. Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study. JAMA Cardiol. 2018;3(8):693–702. doi:10.1001/jamacardio.2018.1717
  4. Riboli, E., Hunt, K., Slimani, N., Ferrari, P., Norat, T., Fahey, M., . . . Saracci, R. (2002). European Prospective Investigation into Cancer and Nutrition (EPIC): Study populations and data collection. Public Health Nutrition, 5(6b), 1113-1124. doi:10.1079/PHN2002394
  5. Cano-Marquina, J.J. Tarín, A. Cano,The impact of coffee on health,Maturitas,Volume 75, Issue 1,2013,Pages 7-21,ISSN 0378-5122, https://doi.org/10.1016/j.maturitas.2013.02.002.
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Anna von Büllesheim
Article By Anna von Büllesheim

Anna, a highly experienced Coach and Registered Dietitian with 18 years of expertise, holds an MS in Dietetics and Clinical Nutrition PreventAge®. Her extensive background includes successfully addressing chronic dieting patterns, performance nutrition, and health promotion. With proficiency in Nutritional Counseling, Nutrition Education, Psychology & Motivation, Healing Nutrition, and Performance Coaching, Anna is equipped to provide comprehensive support. She is licensed to practice in Europe, catering to both adolescents and adults, and is a valued member of COFENAT, the Spanish association of natural therapies. Anna's entrepreneurial spirit shines through her involvement in two training projects: one focused on educating pharma and aesthetic professionals in nutritional and nutraceutical advice, and the other dedicated to unlocking human potential and elevating the quality of life to new heights.

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